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One of the most significant victories on this front was secured by 30-year-old Sarah McBride in Delaware, who last night became the first openly trans state senator in U.S. history, as well as that of Taylor Small, who became the first openly trans person to be elected to the Vermont legislature. Another notable win came with the election of Stephanie Byers to the Premium i never dreamed i would grow up to be a super cool mother in law of a freaking awesome son in law but here i am killing it mother t-shirt House of Representatives, becoming the first trans Indigenous person to hold statewide office. As Danica Roem, who made history three years ago as the first openly trans person to serve in any U.S. state legislature, noted on Twitter: “Before I ran in ’17, we had no out trans state legislators. In ’21, we’ll have seven.”

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Until recently, many drugs used by doctors for migraines were developed for other conditions, such as epilepsy. But in the Premium i never dreamed i would grow up to be a super cool mother in law of a freaking awesome son in law but here i am killing it mother t-shirt few years, the FDA has approved several new classes of targeted, effective drugs developed specifically for migraines. Even better, they have markedly fewer side effects than commonly used tryptamine-based drugs, also known as triptans, which have been prescribed since the early ’90s to relieve headaches but often come with major side effects such as nausea, insomnia, or hair loss. CGRP inhibitors, medications that block calcitonin gene-related peptide—a protein released by the brain during migraine attacks (and “a very ugly, cumbersome name,” says Gottschalk)—are among the most promising. Three of these prescription-only drugs—Aimovig, Ajovy, and Emgality—are taken monthly with an EpiPen–like shot; a fourth, Vyepti, is administered via I.V. by a doctor every three months. “These drugs produce great results, in much less time, with almost no side effects,” Gottschalk confirms. Nurtec and Ubrelvy, which are gepants—another new class of FDA-approved medication that also targets CGRP molecules—are formulated to turn off migraines in progress rather than prevent them. “They don’t have quite as much bang for the buck as, say, an injection of [the commonly used triptan] sumatriptan,” says Gottschalk. “But they’re well tolerated and can do a great job.”

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